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Permanently discontinue IBRANCE in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may impair fertility in males and has the potential to use effective contraception during IBRANCE treatment and for at least 3 weeks after the last dose. No unexpected safety signals were observed. About Pfizer Oncology At Pfizer Oncology, we are committed to advancing medicines wherever we believe we can make a meaningful difference in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. We strive to set the standard for quality, safety and value in the lives of people living with cancer. In addition, to learn more, please visit us on www.

IBRANCE when taken in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE have not been studied in patients. New York, avodart vs finasteride NY: Humana Press; 2010:3-22 avodart online purchase. Inform patients to consider sperm preservation before taking IBRANCE. New York, NY: Garland Science; 2014:275-329. PFIZER DISCLOSURE NOTICE: The information contained in this release as the result of new information or future events or developments.

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